Carl Maronich (Host): Welcome to Jamaica Hospital Med Talk, the podcast
of Jamaica Hospital Medical Center.
I'm Carl Maronich, and joining me today is Dr.
Amir Barari, a rheumatologist with Med Sys Health Network,
Jamaica Hospital Medical Center.
And today we're gonna be talking about lupus, a complex autoimmune
disease that impacts many lives.
Doctor, welcome to the podcast.
Dr Amir Barkhodari: Hello, Carl.
Thank you for having me here.
Carl Maronich (Host): Yeah, and we're gonna be talking about lupus.
So maybe let's start with just a, a definition of what Lupus is And
what impact it has on the body.
Dr Amir Barkhodari: So actually I wanted to start with the meaning of word lupus.
The word lupus means wolf in Latin.
So back in the 13th centuries, the doctors noticed that the patient's with
lupus have a facial, markings, a facial rash that resembles the wolf bite.
Or evolve facial markings.
So that's how the disease got its name.
And then, what we know right now is that the lupus as you
said, is a complex disease.
It's an autoimmune disease with chronic inflammation involving different
organs and different parts of the body.
When we usually talk about lupus, we refer it to the main form, which
is the systemic lupus ssis, or SLE.
This form of lupus is a chronic hydrogenous, systemic autoimmune disease.
It's chronic because it tends to last for a long time, often for life.
It's systemic means that it can affect many different parts of the body.
And it's autoimmune means that the immune system.
Instead of only fighting with the germs, bacteria, infections,
viruses, mistakenly attacks, bodies own healthy tissues and organs
overall.
Lupus is a rare disease, And the United States, we have about 1.5
million people living with some form of lupus.
And out of those, roughly about 200,000.
Have confirmed systemic lupus arithmetics, which is the main form of lupus.
Carl Maronich (Host): Yeah.
And Doctor, does it affect men and women equally?
Dr Amir Barkhodari: no.
No.
There are many different risk factors that can prone someone to
be more at-risk of lupus, that we are gonna go over them very soon.
Carl Maronich (Host): Yeah.
And how does it manifest, if you will, in or present in patient's
that, are developing lupus?
Dr Amir Barkhodari: So there are different, symptoms.
Depends, some patient's may have mild disease with very, non-specific symptoms.
Some of the patient's have very, very severe, complicated symptoms.
Involving multiple organs and even sometimes life-threatening organs.
So it's a one disease, but with the different manifestations,
individual, everybody's different.
And, it's a very complex disease as we discussed.
Carl Maronich (Host): So initially a patient may be feeling some kind of
way they go, they are likely gonna start with their primary care physician
who might pick up on some of these things and ultimately refer 'em to you.
A rheumatologist.
Is that how the process would go?
Dr Amir Barkhodari: Correct.
Yes.
usually the patient's would definitely reach out to the
primary care physicians with many different symptoms and complaints.
And usually, the primary care providers screen them and if they have
suspicion for, autoimmune diseases.
Including lupus.
There are some initial tests that they can start with, or they will refer the patient
to their rheumatologist who's a specialist that deals with this type of diseases.
And based on the symptoms, the labs, the presentation as we discuss the sex, the
female or male, the age, we can put all these, information next to each other
and come up with the possibility of.
Carl Maronich (Host): Yeah.
Well, doctor, maybe we could talk a little bit about the signs and symptoms
and, how it might, develop in a patient.
Dr Amir Barkhodari: when we talk about the systemic lupus as we discussed,
so we are talking about a disease that can affect almost any part
of the body, and it can look very different from one person to another.
Some features are very typical to lupus, but many are even not specific.
So that's why it's very hard to diagnose even for some of the clinicians,
including the rheumatologists.
So overall the general symptoms are feeling unwell, fatigue, low grade
fever, loss of appetite, and weight loss.
And skin and mucus membrane involvement like rashes on the body, on the
face, areas with the sun exposure and recurrent sores in the mouth and nose.
And also joint involvement, including the joint pain, joint swelling.
beyond that, systemic lupus can involve the.
Major internal organs, which can be the kidneys, can be the nervous system,
lungs, heart and gastrointestinal tracts.
some people might have very mild disease, as I said, and some may
have the threatening problems.
Carl Maronich (Host): Yeah.
Very, very widespread in terms of the symptoms and on all that you talked about.
So, as you also said, it may manifest very differently in different
patient's, which I'm guessing, would make treatment a bit challenging.
Dr Amir Barkhodari: Absolutely.
Yes.
we always say that it's the same disease, but it can look
very different in each person.
regarding the treatment, there are many options that we can use.
Again, it depends, what are the presentation, what's
the severity of the disease?
Unfortunately, there is no cure for lupus And the main goal is to
calm down the overactive immune system so the immune system would
not continue attacking the body and it would prevent long-term damages.
regarding the medications, we do have corticosteroids.
That something like prednisone, that it can quickly reduce the
inflammation and usually use to lower.
We usually use as a lowest effective dose and as short time as possible.
The next medication that we can use is the hydroxychloroquine, which is
the cornerstone medication for lupus.
Almost most of the patient's with confirmed lupus disease
would be on hydroxychloroquine.
It helps to reduce the flares, improve the skin and joint symptoms.
we do have other immunosuppressive and biologic medications that it
depends on the severity of the disease, which organ is involved And we can
use them to control the disease.
Carl Maronich (Host): so as you mentioned, there's really no cure for systemic lupus.
So This is something someone may be living with for life.
How over the course of time do they manage that disease?
Dr Amir Barkhodari: the most important thing is that to understand that
lupus is a chronic, lifelong disease, it requires a long-term partnership
between a patient and a healthcare team.
So ongoing monitoring is very important.
We regularly check the disease activity.
We watch carefully for any new organ involvement through the symptoms,
physical exam, blood and urine tests.
And that helps us to adjust the treatment early before a significant damage occurs.
So my recommendation for self-management, um, strategies beyond the medication
care is that protecting skin from sun exposure is very important.
So I would recommend patient's wear, sunscreen SPF 30 or above and protective
clothing and avoiding peak sun hours from 10:00 AM to 3:00 PM getting adequate rest.
Rest is very important for immune system exercising regularly and eating healthy.
Carl Maronich (Host): Doctor because it's an autoimmune disease, I would guess that.
Patient's with lupus may also be susceptible to other things, which would
mean they'd have to be careful regarding other potential diseases and such.
is that something that, is, an issue for lupus patient's?
Dr Amir Barkhodari: So we always have overlap diseases.
the autoimmune diseases is a spectrum of diseases that patient's may present
with different symptoms, and when the rheumatologists put them together,
they can come up with the diagnosis Of these autoimmune diseases like lupus.
But some of the lupus patient's may have features of the other diseases
like Sjogren's syndrome, like rheumatoid arthritis, like systemic sclerosis,
and again, based on the symptoms.
We will, define the disease we sometimes call the lupus.
Sometime we call the patient has lupus with overlap syndrome.
but again, as I said, every patient has a different presentation.
And, the treatment also would be the different based on the presentations.
Carl Maronich (Host): What are individuals who may have a family
member that has lupus and therefore they're, close to their family and
they maybe even some forms a caregiver.
what recommendations would you make to them?
Dr Amir Barkhodari: if you want to talk about the risk factors, I have to
mention that, as we know, women, Are the majority of the lupus patient's.
So 90% of the patient's with lupus are women, And in a child
bearing ages from age 15 to 45.
And some ethnicities also are more at-risk of getting, lupus like
non-Hispanic Blacks, Hispanics, Asians, and native Americans com
compared to the white population, as you said, the family history.
The family history of lupus or any other autoimmune disease increased
the risk, but not everyone who has a family member of lupus would
get the disease is not inherited.
Basically, as I said, it is a heterogeneous disease.
There are many, many different factors that play a role for
someone who's susceptible genetically to end up getting lupus.
Carl Maronich (Host): Yeah.
a lot of great information.
Dr.
Marco o thanks so much for joining us today.
Any, you wanna mention to folks who may be listening and who are, are battling
or have a family member that has lupus?
Dr Amir Barkhodari: Absolutely.
I would like to, emphasize that any patient with lupus should have a
close, partnership and, close follow-up with, the rheumatologist to make
sure that the disease is controlled.
This is a chronic disease that.
Might have very silent, continuous damages and joint and organ involvement without
having any symptoms in a real life.
And the doctors, the rheumatologists have to many tests to find out that
everything is quiet and controlled.
So, the close, partnership with the rheumatologist And the primary
care doctor would be the best, recommendation that I have for the lupus
patient's.
Carl Maronich (Host): Dr.
Amir Arco, thank you so much for joining us and again, sharing all that
very helpful, important information.
Dr Amir Barkhodari: That was my pleasure.
Thank you so much for having me.
Carl Maronich (Host): For more information about the services Jamaica
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